I got to play with a 49+, CNA515... with the newest keys and the latest ROM. It was the first decent 49+ I've seen, what HP should have released in the first place. From the source who got the calc it's all HP can do to just to keep up with bug fixes. With the layoffs at HP, I wouldn't expect anything new.
TI's calculator division is raking in megabucks with very little effort these days, having completely cornered the educational market. Thus, here is no incentive currently to spend any money on developing anything new. The only thing new seem to be re-releases of existing models with new cases in an attempt to appeal to kiddies wanting a bizarre ultra-modern look.
Casio and Sharp continue to produce calcs that have a rather small market share. Casio actually may be the most innovative, coming up with a number of new models. These machines always to have some shortcoming, though. As an example, the Casio ClassPad had a pretty good computer algebra system, but lacked built-in units needed for science/engineering classes. Also, the OS of the ClassPad is poor for serious programming, a real shame.