Too many shifts for my taste, and one key too much. The real Prime already has three functions printed on nearly each key, which may be a good compromise.
Could fly but with a better contrast of legends. And please look for shorter legends or they will be hardly readable. Yes, there's one key too much in the ENTER row.
Just my 20m€.
d:-)
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Oh well, I'd say it can be misleading (and it's a bad habit) to edit an initial post _after_ some replies were made.
In this case it's even worse because the added skins for Emu48g+ have next to nothing to do with the original initial post, and the replies were for the initial post _before_ the reassignment.
The formatting is terrible (consider moving letters off key tops like the WP-34S).
The layout seem to have arbitrary rearrangements for no improvement (shifted SYMB, Toolbox key).
I think having a second shift key is a good move, but I don't think this is a great design for using one.